The advent of digital tools in the field of “Digital Humanities” has enabled a profound reconsideration of the methodology in Orientalist studies of the Prophetic biography (Sīrah). This article aims to present an interdisciplinary framework for data-driven analysis of the biography of the Prophet of Islam (PBUH) with a focus on the Qur’an as the central text. Based on a descriptive–analytical method and a systematic review of digital resources, it introduces key tools and databases such as the Qur’anic Arabic Corpus, OpenITI, and Digital Hadith, explaining the general mechanisms of data extraction and refinement. Three main axes were analyzed: the alignment of Prophetic narrations with Qur’anic verses through advanced search, semantic analysis of key vocabulary in the Sīrah and Qur’anic texts, and exploration of the social network of Hadith narrators, revealing these tools’ capabilities to clarify the semantic and documentary structures of the Sīrah. Findings indicate that integrating these approaches simultaneously enables better understanding of the relationship between the revealed text and historical narration, identification of shared semantic patterns, and enhancement of documentary authentication. Moreover, innovative reference sources like the Encyclopedia of the Qur’an, Brill’s Encyclopedia of Islam, and Oxford Islamic Studies Online provide an integrated infrastructure for combining historical, linguistic, and interpretative analyses. Finally, it is recommended that Muslim researchers leverage trilingual databases, design indigenous semantic modules, and integrate digital hermeneutics with classical exegesis to balance the precision of new technologies with the richness of traditional interpretation, thereby strengthening the scientific civilizational dialogue between East and West based on Sīrah data.